SIRT1 and Neural Cell Fate Determination

被引：33

作者：

Cai, Yulong ^{[1
]}

Xu, Le ^{[1
]}

Xu, Haiwei ^{[2
]}

Fan, Xiaotang ^{[1
]}

机构：

[1] Third Mil Med Univ, Sch Psychol, Dept Dev Neuropsychol, Chongqing 400038, Peoples R China

[2] Third Mil Med Univ, Southwest Hosp, Southwest Eye Hosp, Chongqing 400038, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 05期

关键词：

SIRT1; Neural stem cells; Neuron; Differentiation; Deacetylation; EMBRYONIC STEM-CELLS; NUCLEAR RECEPTOR TLX; NEURONAL DIFFERENTIATION; DEACETYLASE SIRT1; SELF-RENEWAL; DNA-DAMAGE; TRANSCRIPTIONAL ACTIVATION; HISTONE DEACETYLASE; PROGENITOR CELLS; MAMMALIAN HAIRY;

D O I：

10.1007/s12035-015-9158-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During the development of the central nervous system (CNS), neurons and glia are derived from multipotent neural stem cells (NSCs) undergoing self-renewal. NSC commitment and differentiation are tightly controlled by intrinsic and external regulatory mechanisms in space- and time-related fashions. SIRT1, a silent information regulator 2 (Sir2) ortholog, is expressed in several areas of the brain and has been reported to be involved in the self-renewal, multipotency, and fate determination of NSCs. Recent studies have highlighted the role of the deacetylase activity of SIRT1 in the determination of the final fate of NSCs. This review summarizes the roles of SIRT1 in the expansion and differentiation of NSCs, specification of neuronal subtypes and glial cells, and reprogramming of functional neurons from embryonic stem cells and fibroblasts. This review also discusses potential signaling pathways through which SIRT1 can exhibit versatile functions in NSCs to regulate the cell fate decisions of neurons and glia.

引用

页码：2815 / 2825

页数：11

共 123 条

[1] miR-34a Regulates Mouse Neural Stem Cell Differentiation [J].

Aranha, Marcia M. ;

Santos, Daniela M. ;

Sola, Susana ;

Steer, Clifford J. ;

Rodrigues, Cecilia M. P. .

PLOS ONE, 2011, 6 (08)

[2] Caspases and p53 Modulate FOXO3A/Id1 Signaling During Mouse Neural Stem Cell Differentiation [J].

Aranha, Marcia M. ;

Sola, Susana ;

Low, Walter C. ;

Steer, Clifford J. ;

Rodrigues, Cecilia M. P. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 107 (04) :748-758

[3] p53 REGULATES THE SELF-RENEWAL AND DIFFERENTIATION OF NEURAL PRECURSORS [J].

Armesilla-Diaz, A. ;

Bragado, P. ;

del Valle, I. ;

Cuevas, E. ;

Lazaro, I. ;

Martin, C. ;

Cigudosa, J. C. ;

Silva, A. .

NEUROSCIENCE, 2009, 158 (04) :1378-1389

[4] Epigenetic protein families: a new frontier for drug discovery [J].

Arrowsmith, Cheryl H. ;

Bountra, Chas ;

Fish, Paul V. ;

Lee, Kevin ;

Schapira, Matthieu .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (05) :384-400

[5] Mechanism of sirtuin inhibition by nicotinamide:: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme [J].

Avalos, JL ;

Bever, KM ;

Wolberger, C .

MOLECULAR CELL, 2005, 17 (06) :855-868

[6] Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture [J].

Bain, G ;

Ray, WJ ;

Yao, M ;

Gottlieb, DI .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 223 (03) :691-694

[7] EMBRYONIC STEM-CELLS EXPRESS NEURONAL PROPERTIES IN-VITRO [J].

BAIN, G ;

KITCHENS, D ;

YAO, M ;

HUETTNER, JE ;

GOTTLIEB, DI .

DEVELOPMENTAL BIOLOGY, 1995, 168 (02) :342-357

[8] SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation [J].

Barber, Matthew F. ;

Michishita-Kioi, Eriko ;

Xi, Yuanxin ;

Tasselli, Luisa ;

Kioi, Mitomu ;

Moqtaderi, Zarmik ;

Tennen, Ruth I. ;

Paredes, Silvana ;

Young, Nicolas L. ;

Chen, Kaifu ;

Struhl, Kevin ;

Garcia, Benjamin A. ;

Gozani, Or ;

Li, Wei ;

Chua, Katrin F. .

NATURE, 2012, 487 (7405) :114-+

[9]

Barbieri AM, 2002, DEVELOPMENT, V129, P805

[10] Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation [J].

Beuckmann, CT ;

Yanagisawa, M .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2002, 80 (06) :329-342

← 1 2 3 4 5 6 7 8 9 10 →