Total synthesis of the cytotoxic Annonaceous acetogenin (30S)-bullanin

被引：34

作者：

Marshall, JA ^{[1
]}

Hinkle, KW ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10739-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of (+)-(30S)-bullanin, a highly cytotoxic Annonaceous acetogenin, was effected by a convergent approach in which the key core bis-2,2'-tetrahydrofuran stereocenters were introduced through a combination of Sharpless asymmetric dihydroxylation and S(E)2' additions of oxygenated nonracemic allylic stannane and indium reagents to gamma-oxygenated aldehydes. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1303 / 1306

页数：4

共 21 条

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