Cystatin C as a marker of GFR -: history, indications, and future research

被引：582

作者：

Filler, G ^{[1
]}

Bökenkamp, A

Hofmann, W

Le Bricon, T

Martínez-Brú, C

Grubb, A

机构：

[1] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON, Canada

[2] Vrije Univ Amsterdam, Dept Pediat, Med Ctr, Amsterdam, Netherlands

[3] Dept Clin Chem, Munich, Germany

[4] Hop St Louis, Biochim Lab A, F-75010 Paris, France

[5] Hosp Santa Creu & Sant Pau, Serv Bioquim, Barcelona, Spain

[6] Univ Lund Hosp, Dept Clin Chem, S-22185 Lund, Sweden

来源：

CLINICAL BIOCHEMISTRY | 2005年 / 38卷 / 01期

关键词：

cystatin C; GFR; creatinine;

D O I：

10.1016/j.clinbiochem.2004.09.025

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To summarize recent knowledge on the small molecular weight protein cystatin C (cys-C) and its use as a marker of the glomerular filtration rate (GFR). Methods: A multinational expert meeting was held in April 2002 in Marburg, Germany. Contributors summarized their main findings. Conclusions: Cys-C is at least equal if not superior to serum creatinine as a marker of GFR. The independence from height, gender, age. and muscle mass is advantageous. Select patient groups such as children, the elderly, and patients with reduced muscle mass benefit in particular. (C) 2004 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：1 / 8

页数：8

共 86 条

[1] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF CDNA CODING FOR THE PRECURSOR OF THE HUMAN CYSTEINE PROTEINASE-INHIBITOR CYSTATIN-C [J].