Genetics of brain tumors

被引：16

作者：

Weiss, WA ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN PEDIATRICS | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1097/00008480-200012000-00005

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Brain tumors are among the most common forms of cancer in children and account for most cancer-related deaths in this age group. The incidence of brain tumors appears to be increasing in children, while therapeutic advances have been modest. Few genetic studies exist on pediatric brain tumors, in part because tissue from low-grade and brain stem tumors is not readily available, and also because individual centers have relatively few cases. Genetic changes in infiltrating astrocytomas involve genes in the p53 and RE pathways, and show alterations that are similar to infiltrating astrocytomas in adults. The PTC gene is mutated in a subgroup of medulloblastomas, and may lead to increased proliferation in granule cells that normally express this receptor. Further studies are needed to identify genetic alterations in pilocytic and low-grade astrocytomas, which account for 40% of brain tumors in children. (C) 2000 Lippincott Williams & Wilkins, Inc.

引用

页码：543 / 548

页数：6

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