APC gene:: database of germline and somatic mutations in human tumors and cell lines

被引:110
作者
Laurent-Puig, P
Béroud, C
Soussi, T
机构
[1] Hop Laennec, Serv Chirurg Digest Gen & Oncol, F-75007 Paris, France
[2] Hop Necker Enfants Malad, INSERM, U383, Paris, France
[3] Inst Curie, CNRS, UMR 218, F-75231 Paris 05, France
关键词
D O I
10.1093/nar/26.1.269
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A database (http://perso.curie.fr/tsoussi) is described, in which over 1000 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature. It includes both molecular information about the mutations and clinical data about the patients, Software has been designed to analyse all this information in the database.
引用
收藏
页码:269 / 270
页数:2
相关论文
共 20 条
[1]   FAMILIAL ADENOMATOUS POLYPOSIS - DESMOID TUMORS AND LACK OF OPHTHALMIC LESIONS (CHRPE) ASSOCIATED WITH APC MUTATIONS BEYOND CODON-1444 [J].
CASPARI, R ;
OLSCHWANG, S ;
FRIEDL, W ;
MANDL, M ;
BOISSON, C ;
BOKER, T ;
AUGUSTIN, A ;
KADMON, M ;
MOSLEIN, G ;
THOMAS, G ;
PROPPING, P .
HUMAN MOLECULAR GENETICS, 1995, 4 (03) :337-340
[2]  
DAVIES DR, 1995, AM J HUM GENET, V57, P1151
[3]  
Fein M, 1997, Am J Gastroenterol, V92, P359
[4]  
Friedl W, 1996, HUM GENET, V97, P579
[5]   PHENOTYPIC VARIABILITY OF FAMILIAL ADENOMATOUS POLYPOSIS IN 11 UNRELATED FAMILIES WITH IDENTICAL APC GENE MUTATION [J].
GIARDIELLO, FM ;
KRUSH, AJ ;
PETERSEN, GM ;
BOOKER, SV ;
KERR, M ;
TONG, LL ;
HAMILTON, SR .
GASTROENTEROLOGY, 1994, 106 (06) :1542-1547
[6]   Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinoma [J].
Gonzalez, MV ;
Artimez, ML ;
Rodrigo, L ;
LopezLarrea, C ;
Menendez, MJ ;
Alvarez, V ;
Perez, R ;
Fresno, MF ;
Perez, MJ ;
Sampedro, A ;
Coto, E .
JOURNAL OF CLINICAL PATHOLOGY, 1997, 50 (03) :212-217
[7]   Lessons from hereditary colorectal cancer [J].
Kinzler, KW ;
Vogelstein, B .
CELL, 1996, 87 (02) :159-170
[8]   Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC [J].
Laken, SJ ;
Petersen, GM ;
Gruber, SB ;
Oddoux, C ;
Ostrer, H ;
Giardiello, FM ;
Hamilton, SR ;
Hampel, H ;
Markowitz, A ;
Klimstra, D ;
Jhanwar, S ;
Winawer, S ;
Offit, K ;
Luce, MC ;
Kinzler, KW ;
Vogelstein, B .
NATURE GENETICS, 1997, 17 (01) :79-83
[9]  
Marshall B, 1997, HUM MUTAT, V9, P286, DOI 10.1002/(SICI)1098-1004(1997)9:3<286::AID-HUMU14>3.0.CO
[10]  
2-Z