Protein NMR extends into new fields of structural biology

被引：6

作者：

Cooke, RM ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Biomol Struct Unit, Stevenage SG1 2NY, Herts, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(97)80074-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in protein NMR have opened new doors for the understanding of macromolecular structure and interactions. Isotope-labelling approaches have extended the size limit for structure determination, the mapping of protein-ligand interactions is now widely used and has led to a new drug discovery approach, pathways of protein folding processes can be followed, and the structures of molecules from membranes can be determined.

引用

页码：359 / 364

页数：6

共 43 条

[1] TOWARD SOLVING THE FOLDING PATHWAY OF BARNASE - THE COMPLETE BACKBONE C-13, N-15, AND H-1-NMR ASSIGNMENTS OF ITS PH-DENATURED STATE [J].

ARCUS, VL ;

VUILLEUMIER, S ;

FREUND, SMV ;

BYCROFT, M ;

FERSHT, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) :9412-9416

[2] CP-MAS C-13-NMR DIPOLAR CORRELATION SPECTROSCOPY OF C-13-ENRICHED CHLOROSOMES AND ISOLATED BACTERIOCHLOROPHYLL-C AGGREGATES OF CHLOROBIUM-TEPIDUM - THE SELF-ORGANIZATION OF PIGMENTS IS THE MAIN STRUCTURAL FEATURE OF CHLOROSOMES [J].

BALABAN, TS ;

HOLZWARTH, AR ;

SCHAFFNER, K ;

BOENDER, GJ ;

DEGROOT, HJM .

BIOCHEMISTRY, 1995, 34 (46) :15259-15266

[3] Protein folding monitored at individual residues during a two-dimensional NMR experiment [J].

Balbach, J ;

Forge, V ;

Lau, WS ;

vanNuland, NAJ ;

Brew, K ;

Dobson, CM .

SCIENCE, 1996, 274 (5290) :1161-1163

[4] Probing through-bond connectivities and through-space distances in solids by magic-angle-spinning nuclear magnetic resonance [J].

Baldus, M ;

Iuliucci, RJ ;

Meier, BH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (05) :1121-1124

[5] Total correlation spectroscopy in the solid state. The use of scalar couplings to determine the through-bond connectivity [J].

Baldus, M ;

Meier, BH .

JOURNAL OF MAGNETIC RESONANCE SERIES A, 1996, 121 (01) :65-69

[6] SOLID-STATE NMR DETERMINATION OF INTRAMOLECULAR AND INTERMOLECULAR P-31-C-13 DISTANCES FOR SHIKIMATE 3-PHOSPHATE AND [1-C-13]GLYPHOSATE BOUND TO ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE [J].

CHRISTENSEN, AM ;

SCHAEFER, J .

BIOCHEMISTRY, 1993, 32 (11) :2868-2873

[7] MAPPING THE BINDING SURFACE OF INTERLEUKIN-8 COMPLEXED WITH AN N-TERMINAL FRAGMENT OF THE TYPE-1 HUMAN INTERLEUKIN-8 RECEPTOR [J].

CLUBB, RT ;

OMICHINSKI, JG ;

CLORE, GM ;

GRONENBORN, AM .

FEBS LETTERS, 1994, 338 (01) :93-97

[8] KINETIC MECHANISM OF CYTOCHROME-C FOLDING - INVOLVEMENT OF THE HEME AND ITS LIGANDS [J].

ELOVE, GA ;

BHUYAN, AK ;

RODER, H .

BIOCHEMISTRY, 1994, 33 (22) :6925-6935

[9] Initiation sites of protein folding by NMR analysis [J].

Freund, SMV ;

Wong, KB ;

Fersht, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :10600-10603

[10] C-13-C-13 AND C-13-N-15 DIPOLAR CORRELATION NMR OF UNIFORMLY LABELED ORGANIC-SOLIDS FOR THE COMPLETE ASSIGNMENT OF THEIR C-13 AND N-15 SIGNALS - AN APPLICATION TO ADENOSINE [J].

FUJIWARA, T ;

SUGASE, K ;

KAINOSHO, M ;

ONO, A ;

AKUTSU, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (45) :11351-11352

← 1 2 3 4 5 →