Advances in signalling by extracellular nucleotides: the role and transduction mechanisms of P2Y receptors

被引：139

作者：

Communi, D

Janssens, R

Suarez-Huerta, N

Robaye, B

Boeynaems, JM

机构：

[1] Free Univ Brussels, Hop Erasme, Dept Med Chem, B-1070 Brussels, Belgium

[2] Free Univ Brussels, Sch Med, Inst Interdisciplinary Res, B-1000 Brussels, Belgium

来源：

CELLULAR SIGNALLING | 2000年 / 12卷 / 06期

关键词：

nucleotides; purines; G-protein-coupled receptors; P2;

D O I：

10.1016/S0898-6568(00)00083-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two families: the ionotropic P2X receptors and the metabotropic P2Y receptors. Five human P2Y receptor subtypes have been cloned so far and a sixth one must still be isolated. In this review we will show that they differ by their preference for adenine ver-sits uracil nucleotides and triphospho versus diphospho nucleotides, as well as by their transduction mechanisms and cell expression. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：351 / 360

页数：10

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