Omeprazole and clopidogrel: Should clinicians be worried?

被引：27

作者：

Depta, Jeremiah P. ^{[2
]}

Bhatt, Deepak L. ^{[1
,3
,4
,5
]}

机构：

[1] VA Boston Healthcare Syst, Boston, MA 02132 USA

[2] Cleveland Clin, Inst Med, Dept Internal Med, Cleveland, OH 44106 USA

[3] Brigham & Womens Hosp, Integrated Intervent Cardiovasc Program, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] TIMI Study Grp, Boston, MA USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2010年 / 77卷 / 02期

关键词：

PROTON PUMP INHIBITORS; TRIAL; PANTOPRAZOLE; ASPIRIN; THERAPY; RISK;

D O I：

10.3949/ccjm.77a.09173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor.

引用

页码：113 / 116

页数：4

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