AmpC β-lactamase in an Escherichia coli clinical isolate confers resistance to expanded-spectrum cephalosporins

被引：30

作者：

Mammeri, H

Nazic, H

Naas, T

Poirel, L

Léotard, S

Nordmann, P

机构：

[1] Univ Paris Sud, Serv Bacteriol Virol, Hop Bicetre, Fac Med,Assistance Publ Hop Paris, F-94275 Le Kremlin Bicetre, France

[2] Istanbul Univ, Fac Med, Dept Microbiol, Istanbul, Turkey

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 10期

关键词：

D O I：

10.1128/AAC.48.10.4050-4053.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cloning, sequencing, and biochemical analysis identified a novel AmpC-type beta-lactamase conferring resistance to extended-spectrum cephalosporins in an Escherichia coli clinical isolate. This enzyme, exhibiting 14 amino acid substitutions compared to a reference AmpC cephallosporinase of E. coli, hydrolyzed ceftazidime and cefepime significantly.

引用

页码：4050 / 4053

页数：4

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