Capillary electrophoretic separation of the enantiomers of organophosphates with a phosphorus stereogenic center using the sodium salt of octakis(2,3-diacetyl-6-sulfo)-γ-cyclodextrin as resolving agent

被引：18

作者：

Zhu, WH ^{[1
]}

Wu, FY ^{[1
]}

Raushel, FM ^{[1
]}

Vigh, G ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 895卷 / 1-2期

关键词：

enantiomer seperation; background electrolyte composition; organophosphorous compounds; phosphates; cyclodextrins;

D O I：

10.1016/S0021-9673(00)00663-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The sodium salt of the single-isomer, chiral resolving agent, octakis(2,3-diacetyl-6-sulfo)-gamma -cyclodextrin (ODAS-gamma CD) has been used for the capillary electrophoretic separation of the enantiomers of alkylarylphosphates which carry a phosphorus-based stereogenic center. The effective mobilities and separation selectivities were measured at different ODAS-gamma CD and methanol concentrations to find the conditions under which the minor enantiomers could be adequately quantitated in samples obtained by chemical resolution of the racemic mixtures. This work extends the utility of ODAS-gamma CD to a hitherto unexplored field, the capillary electrophoretic separation of the enantiomers of organophosphorus compounds. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：247 / 254

页数：8

共 23 条

[1]

Beale SC, 1998, ANAL CHEM, V70, p279R

[2] Capillary electrophoretic separation of enantiomers using the single isomer heptakis-(2,3-dimethyl-6-sulfato)-β-cyclodextrin as chiral resolving agent in methanol-water background electrolytes [J].