Expression and motor effects of secretin in small and large intestine of the rat

被引：13

作者：

Andersson, A ^{[1
]}

Sundler, F ^{[1
]}

Ekblad, E ^{[1
]}

机构：

[1] Lund Univ, Dept Physiol Sci, Sect Neuroendocrine Cell Biol, Lund, Sweden

来源：

PEPTIDES | 2000年 / 21卷 / 11期

关键词：

VIP; PACAP; secretin receptor; intestinal relaxation; gut hormones;

D O I：

10.1016/S0196-9781(00)00318-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells on duodenal villi with a gradual decrease throughout the small intestines of the rat. They were absent in pancreas, stomach and colon. Secretin caused relaxation of rat intestinal longitudinal muscle in vitro. Studies on colon revealed that the secretin-evoked response was unaffected by apamin, tetrodotoxin, L-NAME, VIP or PACAP pretreatment; secretin itself caused desensitization. Addition of VIP or PACAP when the secretin-evoked relaxation was maximal evoked a further relaxation suggesting the presence of distinct receptors. Secretin causes relaxation via activation of secretin receptors located on the smooth muscle and not via any of the related VIP/PACAP receptors. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1687 / 1694

页数：8

共 20 条

[1]

Bayliss WM, 1902, J PHYSIOL-LONDON, V28, P325

[2]

Chey WY, 1999, GASTROENTEROLOGY, V116, pA597

[3]

PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDES, PACAP-27 AND PACAP-38 - STIMULATORS OF ELECTROGENIC ION SECRETION IN THE RAT SMALL-INTESTINE [J].