Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance

被引：289

作者：

Ang, WH

Khalaila, I

Allardyce, CS

Juillerat-Jeanneret, L

Dyson, PJ ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, BCH, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[2] Univ Lausanne, CHU Vaudois, Inst Pathol, CH-1011 Lausanne, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 05期

关键词：

D O I：

10.1021/ja0432618

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described. Copyright © 2005 American Chemical Society.

引用

页码：1382 / 1383

页数：2

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