The effect of diabetes mellitus on osseous healing

被引：188

作者：

Retzepi, M. ^{[1
]}

Donos, N. ^{[1
]}

机构：

[1] UCL Eastman Dent Inst, Div Clin Res, Periodontol Unit, London WC1X 8LD, England

来源：

CLINICAL ORAL IMPLANTS RESEARCH | 2010年 / 21卷 / 07期

关键词：

bone healing; diabetes mellitus; hyperglycaemia; insulin; ossification; BONE-MINERAL DENSITY; GLYCATION END-PRODUCTS; ALKALINE-PHOSPHATASE ACTIVITY; METABOLIC-CONTROL; GROWTH-FACTOR; GLUCOSE-TRANSPORT; INSULIN INCREASES; TYPE-1; RAT; EXPRESSION;

D O I：

10.1111/j.1600-0501.2010.01923.x

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Diabetes mellitus and, in particular, type 1 diabetes has been associated with impaired osseous wound healing properties. The scope of the present review is to discuss the clinical evidence supporting a higher rate of complications during fracture healing in diabetic patients and the histological evidence indicating impaired potential for intramembranous and endochondral ossification in the presence of uncontrolled experimental diabetes. The article further provides a synthesis of our current understanding of the plausible molecular mechanisms underlying the diabetic bone healing pathophysiology and of the role of insulin treatment in promoting osseous healing in the diabetic status. To cite this article:Retzepi M, Donos N. The effect of diabetes mellitus on osseous healing.Clin. Oral Impl. Res. 21, 2010; 673-681.doi: 10.1111/j.1600-0501.2010.01923.x.

引用

页码：673 / 681

页数：9

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