ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men

被引：110

作者：

Chion, Chan K. N. K.

Doggen, Carine J. M.

Crawley, James T. B.

Lane, David A.

Rosendaal, Frits R.

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Haematol, London W12 0NN, England

[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol & Hemostasis, NL-2300 RA Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Thrombosis Res Ctr, NL-2300 RA Leiden, Netherlands

来源：

BLOOD | 2007年 / 109卷 / 05期

关键词：

D O I：

10.1182/blood-2006-07-038166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Von Willebrand factor (VWF) mediates the tethering/adhesion of platelets at sites of vascular injury. This function depends on its multimeric size, which is controlled by ADAMTS13. We measured plasma ADAMTS13 and VWF antigen levels by enzyme-linked immunosorbent assay (ELISA) in a large population-based case-control study (Study of Myocardial Infarctions Leiden [SMILE]), consisting of 560 men with a first myocardial infarction (MI) and 646 control subjects. Although ABO blood groups influenced VWF levels, they had no influence on ADAMTS13. Furthermore, there was no relationship between plasma ADAMTS13 and VWF levels. Similar to VWF, the estimated risk of MI was increased for every quartile of ADAMTS13 when compared to the lowest quartile (odds ratio, 1.5-1.6). If confirmed, the association of ADAMTS13 with MI may suggest an unexpected mechanistic action of ADAMTS13.

引用

收藏

页码：1998 / 2000

页数：3

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