Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats

被引：79

作者：

Wang, J ^{[1
]}

Leibowitz, KL ^{[1
]}

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

来源：

BRAIN RESEARCH | 1997年 / 777卷 / 1-2期

关键词：

neuropeptide Y; galanin; insulin; hypothalamus; arcuate nucleus; paraventricular nucleus;

D O I：

10.1016/S0006-8993(97)00963-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The central actions of insulin, on galanin (GAL) and neuropeptide Y (NPY) in the brain, are examined in intact satiated rats. Ventricular injections of insulin reduce both GAL and NPY gene expression and immunoreactivity in different hypothalamic areas but have no effect in extra-hypothalamic sites. Insulin applied to medial hypothalamic fragments in vitro significantly reduces GAL and NPY release. This evidence suggests that insulin acts centrally and directly on hypothalamic peptide activity under normal feeding conditions. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：231 / 236

页数：6

相关论文

共 31 条

[1] INCREASED NEUROPEPTIDE-Y CONTENT IN THE ARCUATO-PARAVENTRICULAR HYPOTHALAMIC NEURONAL SYSTEM IN BOTH INSULIN-DEPENDENT AND NON-INSULIN-DEPENDENT DIABETIC RATS [J].

ABE, M ;

SAITO, M ;

IKEDA, H ;

SHIMAZU, T .

BRAIN RESEARCH, 1991, 539 (02) :223-227

[2] HYPOTHALAMIC GALANIN-LIKE IMMUNOREACTIVITY AND ITS GENE-EXPRESSION IN RELATION TO CIRCULATING CORTICOSTERONE [J].

AKABAYASHI, A ;

WATANABE, Y ;

GABRIEL, SM ;

CHAE, HJ ;

LEIBOWITZ, SF .

MOLECULAR BRAIN RESEARCH, 1994, 25 (3-4) :305-312

[3] HYPOTHALAMIC NEUROPEPTIDE-Y AND ITS GENE-EXPRESSION - RELATION TO LIGHT/DARK CYCLE AND CIRCULATING CORTICOSTERONE [J].

AKABAYASHI, A ;

LEVIN, N ;

PAEZ, X ;

ALEXANDER, JT ;

LEIBOWITZ, SF .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1994, 5 (03) :210-218

[4] HYPOTHALAMIC NEUROPEPTIDE-Y, ITS GENE-EXPRESSION AND RECEPTOR ACTIVITY - RELATION TO CIRCULATING CORTICOSTERONE IN ADRENALECTOMIZED RATS [J].

AKABAYASHI, A ;

WATANABE, Y ;

WAHLESTEDT, C ;

MCEWEN, BS ;

PAEZ, X ;

LEIBOWITZ, SF .

BRAIN RESEARCH, 1994, 665 (02) :201-212

[5] DIURNAL RHYTHM OF GALANIN-LIKE IMMUNOREACTIVITY IN THE PARAVENTRICULAR AND SUPRACHIASMATIC NUCLEI AND OTHER HYPOTHALAMIC AREAS [J].

AKABAYASHI, A ;

ZAIA, CTBV ;

KOENIG, JI ;

GABRIEL, SM ;

SILVA, I ;

LEIBOWITZ, SF .

PEPTIDES, 1994, 15 (08) :1437-1444

[6] EFFECT OF PROGESTERONE ON GALANIN MESSENGER-RNA LEVELS IN THE HYPOTHALAMUS AND THE PITUITARY - CORRELATION WITH THE GONADOTROPIN SURGE [J].

BRANN, DW ;

CHORICH, LP ;

MAHESH, VB .

NEUROENDOCRINOLOGY, 1993, 58 (05) :531-538

[7] Central insulin and macronutrient intake in the rat [J].

Chavez, M ;

Riedy, CA ;

VanDijk, G ;

Woods, SC .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1996, 271 (03) :R727-R731

[8]

HIGUCHI H, 1988, J BIOL CHEM, V263, P6288

[9] NEUROPEPTIDE-Y PROJECTION FROM ARCUATE NUCLEUS TO PARVOCELLULAR DIVISION OF PARAVENTRICULAR NUCLEUS - SPECIFIC RELATION TO THE INGESTION OF CARBOHYDRATE [J].

JHANWARUNIYAL, M ;

BECK, B ;

JHANWAR, YS ;

BURLET, C ;

LEIBOWITZ, SF .

BRAIN RESEARCH, 1993, 631 (01) :97-106

[10] Nutritional infertility: The role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network [J].

Kalra, SP ;

Kalra, PS .

FRONTIERS IN NEUROENDOCRINOLOGY, 1996, 17 (04) :371-401

← 1 2 3 4 →