KIR receptors and HLA-C in the maintenance of pregnancy

被引：35

作者：

Flores, A. C.

Marcos, C. Y.

Paladino, N.

Arruvito, L.

Williams, F.

Middleton, D.

Fainboim, L.

机构：

[1] Univ Buenos Aires, Hosp Clin Jose San Martin, Div Inmunogenet, Fac Med, RA-1120 Buenos Aires, DF, Argentina

[2] Belfast City Hosp, No Ireland Reg Histocompatibil & Immunogenet Lab, Belfast BT9 7AD, Antrim, North Ireland

[3] Univ Ulster, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

TISSUE ANTIGENS | 2007年 / 69卷

基金：

英国惠康基金;

关键词：

HLA; killer immunoglobulin-like receptors; natural killer cells; recurrent spontaneous abortions;

D O I：

10.1111/j.1399-0039.2006.762_8.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.

引用

页码：112 / 113

页数：2

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