Polar assembly in a designed protein fiber

被引：55

作者：

Smith, AM

Acquah, SFA

Bone, N

Kroto, HW

Ryadnov, MG

Stevens, MSP

Walton, DRM

Woolfson, DN ^{[1
]}

机构：

[1] Univ Sussex, Sch Life Sci, Dept Biochem, Brighton BN1 9QG, E Sussex, England

[2] Univ Sussex, Sch Life Sci, Dept Chem, Brighton BN1 9QG, E Sussex, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 02期

关键词：

fibrous proteins; nanostructures; peptides; protein design; self-assembly;

D O I：

10.1002/anie.200461599

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bioinspiration: Polar assembly (a feature of many natural protein-based fibrous structures, such as actin, microtubules, intermediate filaments, and collagens) is demonstrated in a straightforward, synthetic, peptide-based fiber system of de novo design (see false-color confocal-microscope image of fibers). This finding opens up possibilities for engineering self-assembling soft materials from the bottom up and with nano-to-microscale precision.

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收藏

页码：325 / 328

页数：4

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