Targeting Apoptosis in the Heart of Streptozotocin-Induced Diabetic Rats

被引:41
作者
Baraka, Azza [1 ]
AbdelGawad, Hala [2 ]
机构
[1] Univ Alexandria, Fac Med, Dept Clin Pharmacol, Alexandria, Egypt
[2] Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt
关键词
diabetic cardiomyopathy; apoptosis; PPARs; fibrates; glitazones; left ventricular hypertrophy; ACTIVATED RECEPTOR-ALPHA; TUMOR-NECROSIS-FACTOR; PEROXISOME PROLIFERATOR; OXIDATIVE STRESS; EXPRESSION; MICE; CARDIOMYOPATHY; IDENTIFICATION; HYPERTROPHY; METABOLISM;
D O I
10.1177/1074248409356557
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: The aim of the current study was to address the issue of cardiomyocyte apoptosis as a possible contributor in the development of diabetic cardiomyopathy and whether it would be possible to suppress this apoptosis by the use of a peroxisome proliferator-activated receptor (PPAR)-alpha agonist (fenofibrate) or a PPAR-gamma agonist (rosiglitazone). Methods: Ten normal male albino rats (group I) were injected intraperitoneally (IP) by a single dose of saline and served as a control for group II. Thirty male albino rats were made diabetic by IP streptozotocin (STZ) injection and were divided into 3 groups: group II (nontreated diabetic rats), groups III and IV (diabetic rats treated with PPAR-gamma agonist (rosiglitazone), and PPAR-alpha agonist (fenofibrate) respectively, for 12 weeks starting 1 week following STZ injection. Results: The studied drugs decreased left ventricular to body weight ratio and cardiac: caspase-3, tumor necrosis factor-alpha, hydroxyproline, free fatty acids (FFAs) as well as triglycerides (TGs) and improved oxidative stress parameters as well as left ventricular papillary muscle developed tension (DT). Conclusions: The results of the current study support the hypothesis that apoptosis plays a key role in the pathophysiology of diabetic cardiomyopathy and demonstrate that the use of PPAR-alpha and -gamma agonists might have a protective role against diabetic cardiomyopathy.
引用
收藏
页码:175 / 181
页数:7
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