Liposome production by microfluidics: potential and limiting factors

被引：322

作者：

Carugo, Dario ^{[1
,2
]}

Bottaro, Elisabetta ^{[3
]}

Owen, Joshua ^{[1
]}

Stride, Eleanor ^{[1
]}

Nastruzzi, Claudio ^{[3
]}

机构：

[1] Univ Oxford, Dept Engn Sci, Inst Biomed Engn, Old Rd Campus Res Bldg, Oxford, England

[2] Univ Southampton, Fac Engn & Environm, Mechatron & Bioengn Sci Res Grp, Southampton, Hants, England

[3] Univ Ferrara, Dept Life Sci & Biotechnol, I-44100 Ferrara, Italy

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

英国工程与自然科学研究理事会;

关键词：

MONODISPERSE; ENCAPSULATION; VESICLES; DEVICES; SYSTEMS;

D O I：

10.1038/srep25876

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.

引用

页数：15

共 36 条

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Functional Reconstitution of a Voltage-Gated Potassium Channel in Giant Unilamellar Vesicles [J].