The TRPV6 gene, cDNA and protein

被引：59

作者：

Hirnet, D ^{[1
]}

Olausson, J ^{[1
]}

Fecher-Trost, C ^{[1
]}

Bödding, M ^{[1
]}

Nastainczyk, W ^{[1
]}

Wissenbach, U ^{[1
]}

Flockerzi, V ^{[1
]}

Freichel, M ^{[1
]}

机构：

[1] Univ Saarland, D-66421 Homburg, Germany

来源：

CELL CALCIUM | 2003年 / 33卷 / 5-6期

关键词：

TRPV6; gene; CaT1; CaT-L; calmodulin; calcium channel;

D O I：

10.1016/S0143-4160(03)00066-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mouse TRPV6 gene is localized on chromosome 6 and extends over 15.66 kb. The encoded protein comprises 727 amino acid residues with a calculated relative molecular mass of 83,210 Da. TRPV6 is glycosylated and both variants, the glycosylated and the de-glycosylated proteins, are recognized by various polyclonal. and monoclonal antibodies, which were raised against TRPV6. Like human TRPV6, mouse TRPV6 binds calmodulin in the presence, but not in the absence of Ca2+. TRPV6 is abundantly expressed in mouse pancreas and placenta, and to a much lesser extend in mouse stomach and kidney. No transcript expression was detected in poly(A)(+)RNA isolated from heart, brain, intestine, esophagus or aortic endothelial cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：509 / 518

页数：10

共 29 条

[1] ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[2] The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells
Bödding, M
Wissenbach, U
Flockerzi, V
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) : 36656 - 36664
[3] Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion
Freichel, M
ZinkLorenz, A
Holloschi, A
Hafner, M
Flockerzi, V
Raue, F
[J]. ENDOCRINOLOGY, 1996, 137 (09) : 3842 - 3848
[4] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
HAMILL, OP
MARTY, A
NEHER, E
SAKMANN, B
SIGWORTH, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100
[5] ECaC:: the gatekeeper of transepithelial Ca2+ transport
Hoenderop, JGJ
Nilius, B
Bindels, RJM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2002, 1600 (1-2): : 6 - 11
[6] Hoenderop JGJ, 2001, J PHYSIOL-LONDON, V537, P747
[7] Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia
Hoenderop, JGJ
van der Kemp, AWCM
Hartog, A
van de Graaf, SFJ
van Os, CH
Willems, PHGM
Bindels, RJM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) : 8375 - 8378
[8] The TRP channels, a remarkably functional family
Montell, C
Birnbaumer, L
Flockerzi, V
[J]. CELL, 2002, 108 (05) : 595 - 598
[9] A unified nomenclature for the superfamily of TRP cation channels
Montell, C
Birnbaumer, L
Flockerzi, V
Bindels, RJ
Brudorf, EA
Caterina, MJ
Clapham, DE
Harteneck, C
Heller, S
Julius, D
Kojima, I
Mori, Y
Penner, R
Prawitt, D
Scharenberg, AM
Schultz, G
Shimizu, N
Zhu, MX
[J]. MOLECULAR CELL, 2002, 9 (02) : 229 - 231
[10] ISOLATION AND CHARACTERIZATION OF A MONOCLONAL ANTI-PROTEIN KINASE CK2 BETA-SUBUNIT ANTIBODY OF THE IGG CLASS FOR THE DIRECT-DETECTION OF CK2 BETA-SUBUNIT IN TISSUE-CULTURES OF VARIOUS MAMMALIAN-SPECIES AND HUMAN TUMORS
NASTAINCZYK, W
SCHMIDTSPANIOL, I
BOLDYREFF, B
ISSINGER, OG
[J]. HYBRIDOMA, 1995, 14 (04): : 335 - 339

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