Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction

被引：48

作者：

Jennings, LD

Foreman, KW

Rush, TS

Tsao, DHH

Mosyak, L

Kincaid, SL

Sukhdeo, MN

Sutherland, AG

Ding, WD

Kenny, CH

Sabus, CL

Liu, HL

Dushin, EG

Moghazeh, SL

Labthavikul, P

Petersen, PJ

Tuckman, M

Ruzin, AV

机构：

[1] Wyeth Res, Chem & Screening Sci, Pearl River, NY 10965 USA

[2] Wyeth Res, Dept Med Chem, Pearl River, NY 10965 USA

[3] Wyeth Res, Dept Biophys Enzymol, Pearl River, NY 10965 USA

[4] Wyeth Res, Dept Chem Technol, Pearl River, NY 10965 USA

[5] Wyeth Res, Dept Infect Dis Discovery Res, Pearl River, NY 10965 USA

[6] Wyeth Res, Dept Computat Chem, Cambridge, MA 02140 USA

[7] Wyeth Res, Dept Struct Biol, Cambridge, MA 02140 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 19期

关键词：

D O I：

10.1016/j.bmc.2004.07.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ZipA-FtsZ protein-protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were demonstrated to bind to the FtsZ binding domain of ZipA by HSQC NMR and to inhibit cell division in a cell elongation assay. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5115 / 5131

页数：17

共 26 条

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