Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action

被引：26

作者：

Freisz, Severine ^{[2
]}

Bec, Guillaume ^{[2
]}

Radi, Marco ^{[1
]}

Wolff, Philippe ^{[2
]}

Crespan, Emmanuele ^{[3
]}

Angeli, Lucilla ^{[1
]}

Dumas, Philippe ^{[2
]}

Maga, Giovanni ^{[3
]}

Botta, Maurizio ^{[1
]}

Ennifar, Eric ^{[2
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

[2] Univ Strasbourg, CNRS, Architecture & React ARN, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

[3] CNR, IGM, I-27100 Pavia, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 10期

关键词：

competitive inhibitors; enzyme models; HIV-1 reverse transcriptase; molecular modeling; structure elucidation; CONFORMATIONAL-CHANGES; RESISTANCE; MUTATIONS; POLYMERIZATION; COMPLEXES; RELEVANT;

D O I：

10.1002/anie.200905651

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Seeing the sites: Unlike classical nonnucleoslde HIV-1 reverse transcriptase (RT) inhibitors (NNRTI; active site in blue), DAVP-1 is a non-nucleoside RT inhibitor that competes with the nucleotide substrate (NcRTI). The X-ray structure of DAVP-1 bound to the unligated RT shows a new inhibitor binding site close to the polymerase active site. (Nucleoside analogue RT inhibitor (NRTI) binding site Is shown in red.) (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KCaA.

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页码：1805 / 1808

页数：4

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