Anti-dermaptophyte activity of phenolic compounds in "Mokusaku-Eki"

被引：25

作者：

Ikegami, F

Sekine, T

Fujii, Y

机构：

[1] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 263, Japan

[2] Tsumura & Co, Chiyoda Ku, Tokyo 102, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1998年 / 118卷 / 01期

关键词：

2,6-dimethoxyphenol; anti-dermatophyte activity; Trichophyton mentagrophytes; folk medicine; mokusaku-eki;

D O I：

10.1248/yakushi1947.118.1_27

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mokusaku-eki, a kind of pyroligneous acid, is a dark brown color solution obtained from the charcoal burner of such Quercus spp. woods as a by-product. This is used as a folk medicine in water eczema. The n-hexane fraction of this solution contained several phenolic compounds such as 4-ethyl-2-methoxyphenol (3) and 2,6-dimethoxyphenol (4), which could not be found in the fresh woods. Among these compounds, 3 has the highest anti-dermaptophyte activity against Trichophyton mentagrophytes at minimum inhibitory concentration (MIG) 150 mu g/ml.

引用

页码：27 / A4

页数：8

共 7 条

[1] SYNTHESIS OF ACTIVE NITROGUAIACOL ETHER DERIVATIVES OF STREPTOMYCIN [J].