Platelets and stromal cell-derived factor-1 in progenitor cell recruitment

被引：69

作者：

Stellos, Konstantinos ^{[1
]}

Gawaz, Meinrad ^{[1
]}

机构：

[1] Univ Klinikum Tubingen, Med Klin 3, D-72076 Tubingen, Germany

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2007年 / 33卷 / 02期

关键词：

platelets; stromal cell-derived factor-1 (SDF-1); progenitor cells; angiogenesis;

D O I：

10.1055/s-2007-969029

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that binds to its sole counterreceptor, CXCR4. It is well reported that the SDF-1/CXCR4 signaling pathway is of vital importance to human development and to various pathophysiological phenomena, including hematopoiesis, angiogenesis, atherosclerosis, cancer growth, metastasis, and human immunodeficiency virus infection. SDF-1 promotes mobilization of bone marrow-derived endothelial progenitor cells (EPCs) to the circulation in response to vascular injury. Recently, we found that platelets express and release SDF-1 into the microcirculation upon activation and we observed that platelet-derived SDF-1 is functionally involved in recruitment of EPCs to arterial thrombi in vivo. This review discusses the unique functions of this chemokine and the newly discovered impact of platelet-derived SDF-1 into the recruitment of progenitor cells to vascular injury areas, and its subsequent effects in atherosclerosis, vascular repair, and angiogenesis.

引用

页码：159 / 164

页数：6

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