An unstable liaison

被引:36
作者
Lengauer, C [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA
关键词
D O I
10.1126/science.1084468
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
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页码:442 / 443
页数:2
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共 20 条
[1]   Genetic instability and darwinian selection in tumours (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) [J].
Cahill, DP ;
Kinzler, KW ;
Vogelstein, B ;
Lengauer, C .
TRENDS IN CELL BIOLOGY, 1999, 9 (12) :M57-M60
[2]   DNA hypomethylation leads to elevated mutation rates [J].
Chen, RZ ;
Pettersson, U ;
Beard, C ;
Jackson-Grusby, L ;
Jaenisch, R .
NATURE, 1998, 395 (6697) :89-93
[3]   Chromosomal instability and tumors promoted by DNA hypomethylation [J].
Eden, A ;
Gaudet, F ;
Waghmare, A ;
Jaenisch, R .
SCIENCE, 2003, 300 (5618) :455-455
[4]   DNA methylation in cancer: too much, but also too little [J].
Ehrlich, M .
ONCOGENE, 2002, 21 (35) :5400-5413
[5]   HYPOMETHYLATION DISTINGUISHES GENES OF SOME HUMAN CANCERS FROM THEIR NORMAL COUNTERPARTS [J].
FEINBERG, AP ;
VOGELSTEIN, B .
NATURE, 1983, 301 (5895) :89-92
[6]   Induction of tumors in mice by genomic hypomethylation [J].
Gaudet, F ;
Hodgson, JG ;
Eden, A ;
Jackson-Grusby, L ;
Dausman, J ;
Gray, JW ;
Leonhardt, H ;
Jaenisch, R .
SCIENCE, 2003, 300 (5618) :489-492
[7]  
JAENISCH R, COMMUNICATION
[8]   The fundamental role of epigenetic events in cancer [J].
Jones, PA ;
Baylin, SB .
NATURE REVIEWS GENETICS, 2002, 3 (06) :415-428
[9]   Reactivating the expression of methylation silenced genes in human cancer [J].
Karpf, AR ;
Jones, DA .
ONCOGENE, 2002, 21 (35) :5496-5503
[10]  
KAUTIAINEN TL, 1986, J BIOL CHEM, V261, P1594