The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage

被引：98

作者：

Bell, S. F. ^{[2
]}

Rayment, R. ^{[2
]}

Collins, P. W.

Collis, R. E. ^{[1
]}

机构：

[1] Univ Wales Hosp, Dept Anaesthesia, Cardiff CF14 4XW, S Glam, Wales

[2] Univ Wales Hosp, Dept Haematol, Cardiff CF14 4XW, S Glam, Wales

来源：

INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA | 2010年 / 19卷 / 02期

关键词：

Fibrinogen concentrate; Obstetric haemorrhage; Hypofibrinogenaemia; DILUTIONAL COAGULOPATHY; TRANSFUSION; GUIDELINES; EFFICACY; RISK; SUBSTITUTION; TOLERABILITY; HEMOSTASIS; MANAGEMENT; DEFICIENCY;

D O I：

10.1016/j.ijoa.2009.08.004

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Haemorrhage is a common complication of childbirth with 0.65% of deliveries associated with significant (>1500 mL) peripartum blood loss. Hypofibrinogenaemia secondary to dilutional and consumptive coagulopathies can be challenging to correct quickly with conventional blood and plasma therapy. Fibrinogen concentrate offers rapid restoration of fibrinogen levels with a small volume infusion and minimal preparation time. It is effective in treating patients with congenital hypofibrinogenaemia, but there are few reports of its use in association with continuing obstetric haemorrhage. Six cases of obstetric haemorrhage, associated with hypofibrinogenaemia, treated with fibrinogen concentrate in conjunction with platelets, fresh frozen plasma, packed red blood cells, uterotonics and obstetric intervention are described. In all cases, laboratory assessed coagulation was rapidly normalised and severe haemorrhage improved. These cases suggest that fibrinogen concentrate may be an effective addition to conventional treatments for obstetric haemorrhage associated with hypofibrinogenaemia. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：218 / 223

页数：6

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