De novo collapsing glomerulopathy in renal allografts

被引:59
作者
Meehan, SM
Pascual, M
Williams, WW
Tolkoff-Rubin, N
Delmonico, FL
Cosimi, AB
Colvin, RB
机构
[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Nephrol, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Transplantat Unit, Boston, MA 02114 USA
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1097/00007890-199805150-00009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Collapsing glomerulopathy is a recently described form of glomerular injury characterized by capillary collapse and visceral epithelial hypercellularity associated with nephrotic range proteinuria and a rapid, progressive decline in renal function. The lesion has rarely been described in allografts, Methods. We reviewed 892 allograft biopsies from a population of 1079 recipients who received renal transplants between 1978 and 1996, Results, Five cases of de novo collapsing glomerulopathy were identified (0.6% of biopsies; 3.2% since 1993), None occurred before 1993, The patients were 31 to 66 years of age and they presented 6 to 25 months after transplantation, The 24-hr urinary protein ranged from 1.8 to 11.8 g, All patients and donors were negative for the human immunodeficiency virus and had no risk factors for human immunodeficiency virus infection. Diffuse or focal, global or segmental collapse of glomerular capillaries, swelling and hypercellularity of the visceral epithelium, hyaline arteriolosclerosis, and interstitial fibrosis were characteristic histologic features. Two cases had concomitant glomerular immune complex deposits. Progressive decline in allograft function occurred within 2-24 months after diagnosis, culminating in return to dialysis in all patients. Conclusion. Collapsing glomerulopathy can arise in renal allografts as a de novo disease. Although its pathogenesis remains to be clarified, it is important to distinguish this lesion in allografts as it can be associated with rapidly progressive graft failure.
引用
收藏
页码:1192 / 1197
页数:6
相关论文
共 17 条
[1]   FREQUENCY OF INTRAENDOTHELIAL VIRUS-LIKE PARTICLES - ELECTRON-MICROSCOPY STUDY OF 376 HUMAN RENAL BIOPSIES [J].
BARIETY, J ;
RICHER, D ;
APPAY, MD ;
GROSSETETE, J ;
CALLARD, P .
JOURNAL OF CLINICAL PATHOLOGY, 1973, 26 (01) :21-24
[2]   FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN RENAL-TRANSPLANTS [J].
CHEIGH, JS ;
MOURADIAN, J ;
SOLIMAN, M ;
TAPIA, L ;
RIGGIO, RR ;
STENZEL, KH ;
RUBIN, AL .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1983, 2 (04) :449-455
[3]   PATHOLOGY OF HIV-ASSOCIATED NEPHROPATHY - A DETAILED MORPHOLOGIC AND COMPARATIVE-STUDY [J].
DAGATI, V ;
SUH, JI ;
CARBONE, L ;
CHENG, JT ;
APPEL, G .
KIDNEY INTERNATIONAL, 1989, 35 (06) :1358-1370
[4]  
Detwiler Randal K., 1996, Journal of the American Society of Nephrology, V7, P1331
[5]   COLLAPSING GLOMERULOPATHY - A CLINICALLY AND PATHOLOGICALLY DISTINCT VARIANT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS [J].
DETWILER, RK ;
FALK, RJ ;
HOGAN, SL ;
JENNETTE, JC .
KIDNEY INTERNATIONAL, 1994, 45 (05) :1416-1424
[6]   Focal segmental glomerulosclerosis associated with nephrotic syndrome in cholesterol atheroembolism: Clinicopathological correlations [J].
Greenberg, A ;
Bastacky, SI ;
Iqbal, A ;
Borochovitz, D ;
Johnson, JP .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 29 (03) :334-344
[7]   INCREASING INCIDENCE OF FOCAL-SEGMENTAL GLOMERULOSCLEROSIS AMONG ADULT NEPHROPATHIES - A 20-YEAR RENAL BIOPSY STUDY [J].
HAAS, M ;
SPARGO, BH ;
COVENTRY, S .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (05) :740-750
[8]  
KEMENY E, 1995, CLIN NEPHROL, V43, P71
[9]   RECURRENT NEPHROTIC SYNDROME IN RENAL-ALLOGRAFTS [J].
KORBET, SM ;
SCHWARTZ, MM ;
LEWIS, EJ .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1988, 11 (03) :270-276
[10]  
MOROZUMI K, 1989, TRANSPLANT P, V21, P282