Synthesis and ESR studies of nitronyl nitroxide-tethered oligodeoxynucleotides

被引:28
作者
Okamoto, A [1 ]
Inasaki, T
Saito, I
机构
[1] Kyoto Univ, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6158510, Japan
[2] Nihon Univ, Sch Engn, NEWCAT Inst, Koriyama, Fukushima 9638642, Japan
[3] Japan Sci & Technol Corp, SORST, Koriyama, Fukushima 9638642, Japan
关键词
pyrene; oligodeoxynucleotide; fluorescence; quadruplex;
D O I
10.1016/j.tetlet.2004.12.012
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We report oil the development of a nucleoside labeled with a nitronyl nitroxide group, U-NN, and the synthesis of oligodeoxynucleotides containing U-NN. The spin signals of U-NN. containing oligodeoxynucleotides varied with the degree of hybridization of the complementary strand and the distance between nitronyl nitroxide spins. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:791 / 795
页数:5
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