T-cell receptor complex is essential for Fas signal transduction

被引：26

作者：

Akimzhanov, Askar M. ^{[1
]}

Wang, Xinmin ^{[1
]}

Sun, Jiaren ^{[2
]}

Boehning, Darren ^{[1
]}

机构：

[1] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Dept Immunol, Galveston, TX 77555 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 34期

基金：

美国国家卫生研究院;

关键词：

apoptosis; calcium; Lck; TYROSINE KINASE; MEDIATED APOPTOSIS; PERIPHERAL-BLOOD; ANTIGEN RECEPTOR; GENETIC-EVIDENCE; FAMILY KINASES; DEATH RECEPTOR; ACTIVATION; CALCIUM; CHAIN;

D O I：

10.1073/pnas.1005419107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Fas receptor (also known as CD95 and APO-1) is a member of the tumor necrosis factor a-family of death receptors that mediate T-cell responses. Here, we show that Fas receptor signaling requires a functional T-cell receptor (TCR) complex. Fas receptor directly binds to and activates TCR components in a stimulus-dependent manner. Fas receptor stimulation does not activate canonical downstream TCR pathways, but instead the TCR complex is required specifically for Fas-mediated calcium release. Importantly, null mutations in Lck, ZAP70, and the TCR alpha- and beta-chains abrogate Fas signaling. Our results reveal a direct role for the TCR complex in mediating Fas-specific signaling events critical for T-cell homeostasis.

引用

页码：15105 / 15110

页数：6

共 33 条

[1] FAS LIGAND MEDIATES ACTIVATION-INDUCED CELL-DEATH IN HUMAN T-LYMPHOCYTES [J].

ALDERSON, MR ;

TOUGH, TW ;

DAVISSMITH, T ;

BRADDY, S ;

FALK, B ;

SCHOOLEY, KA ;

GOODWIN, RG ;

SMITH, CA ;

RAMSDELL, F ;

LYNCH, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :71-77

[2]

August A, 1996, J BIOL CHEM, V271, P10054

[3] THE MECHANISM OF CHROMOSOME-14 INVERSION IN A HUMAN T-CELL LYMPHOMA [J].

BAER, R ;

FORSTER, A ;

RABBITTS, TH .

CELL, 1987, 50 (01) :97-105

[4] Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: Puncta and distal caps [J].

Barr, Valarie A. ;

Bernot, Kelsie M. ;

Srikanth, Sonal ;

Gwack, Yousang ;

Balagopalan, Lakshmi ;

Regan, Carole K. ;

Helman, Daniel J. ;

Sommers, Connie L. ;

Oh-hora, Masatsugu ;

Rao, Anjana ;

Samelson, Lawrence E. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (07) :2802-2817

[5] Protein acylation and localization in T cell signaling (Review) [J].

Bijlmakers, Marie-Jose .

MOLECULAR MEMBRANE BIOLOGY, 2009, 26 (1-2) :93-103

[6] Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis [J].

Boehning, D ;

Patterson, RL ;

Sedaghat, L ;

Glebova, NO ;

Kurosaki, T ;

Snyder, SH .

NATURE CELL BIOLOGY, 2003, 5 (12) :1051-1061

[7] A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways [J].

Boehning, D ;

van Rossum, DB ;

Patterson, RL ;

Snyder, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (05) :1466-1471

[8] T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization [J].

Crotzer, VL ;

Mabardy, AS ;

Weiss, A ;

Brodsky, FM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (07) :981-991

[9]

Dadi S, 2009, ADV EXP MED BIOL, V650, P180

[10] DOMINANT INTERFERING FAS GENE-MUTATIONS IMPAIR APOPTOSIS IN A HUMAN AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME [J].

FISHER, GH ;

ROSENBERG, FJ ;

STRAUS, SE ;

DALE, JK ;

MIDDELTON, LA ;

LIN, AY ;

STROBER, W ;

LENARDO, MJ ;

PUCK, JM .

CELL, 1995, 81 (06) :935-946

← 1 2 3 4 →