Late Effects Surveillance Recommendations among Survivors of Childhood Hematopoietic Cell Transplantation: A Children's Oncology Group Report

被引：143

作者：

Chow, Eric J. ^{[1
,2
]}

Anderson, Lynnette ^{[3
]}

Baker, K. Scott ^{[1
,2
]}

Bhatia, Smita ^{[4
]}

Guilcher, Gregory M. T. ^{[5
,6
]}

Huang, Jennifer T. ^{[7
]}

Pelletier, Wendy ^{[5
,6
]}

Perkins, Joanna L. ^{[8
]}

Rivard, Linda S. ^{[9
]}

Schechter, Tal ^{[10
]}

Shah, Ami J. ^{[11
]}

Wilson, Karla D. ^{[12
]}

Wong, Kenneth ^{[13
]}

Grewal, Satkiran S. ^{[14
]}

Armenian, Saro H. ^{[12
]}

Meacham, Lillian R. ^{[15
]}

Mulrooney, Daniel A. ^{[16
]}

Castellino, Sharon M. ^{[15
]}

机构：

[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle Childrens Hosp, Div Clin Res, Seattle, WA 98195 USA

[2] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle Childrens Hosp, Div Publ Hlth Sci, Seattle, WA 98195 USA

[3] Med Coll Wisconsin, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Milwaukee, WI 53226 USA

[4] Univ Alabama Birmingham, Sch Med, Inst Canc Outcomes & Survivorship, Birmingham, AL USA

[5] Univ Calgary, Alberta Childrens Hosp, Dept Oncol, Calgary, AB, Canada

[6] Univ Calgary, Dept Paediat, Alberta Childrens Hosp, Calgary, AB T2N 1N4, Canada

[7] Harvard Univ, Sch Med, Dept Dermatol, Boston Childrens Hosp, Boston, MA 02115 USA

[8] Childrens Hosp & Clin Minnesota, Dept Canc & Blood Disorders, Minneapolis, MN USA

[9] Advocate Childrens Hosp, Dept Pediat Hematol Oncol, Oak Lawn, IL USA

[10] Hosp Sick Children, Dept Paediat, Toronto, ON M5G 1X8, Canada

[11] Stanford Univ, Div Stem Cell Transplant & Regenerat Med, Lucile Packard Childrens Hosp, Stanford, CA 94305 USA

[12] City Hope Natl Med Ctr, Dept Populat Sci, 1500 E Duarte Rd, Duarte, CA 91010 USA

[13] Univ So Calif, Childrens Hosp Los Angeles, Dept Radiat Oncol, Los Angeles, CA USA

[14] Tufts Univ, Sch Med, Dept Pediat, Baystate Childrens Hosp, Springfield, MA 01199 USA

[15] Emory Univ, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA 30322 USA

[16] Univ Tennessee, Ctr Hlth Sci, Dept Oncol, St Jude Childrens Res Hosp, Memphis, TN 38163 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2016年 / 22卷 / 05期

关键词：

Childhood; Guideline; Hematopoietic cell transplantation; Late effects; Surveillance; Survivor; TERM-FOLLOW-UP; BONE-MARROW-TRANSPLANTATION; INTERNATIONAL CONSENSUS CONFERENCE; BLOOD INSTITUTE/PEDIATRIC BLOOD; SUBSEQUENT MALIGNANT NEOPLASMS; CARDIOVASCULAR RISK-FACTORS; NATIONAL-CANCER-INSTITUTE; YOUNG-ADULT CANCERS; QUALITY-OF-LIFE; MINERAL DENSITY;

D O I：

10.1016/j.bbmt.2016.01.023

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Hematopoietic cell transplantation (HCT) is an important curative treatment for children with high-risk hematologic malignancies, solid tumors, and, increasingly, nonmalignant diseases. Given improvements in care, there are a growing number of long-term survivors of pediatric HCT. Compared with childhood cancer survivors who did not undergo transplantation, HCT survivors have a substantially increased burden of serious chronic conditions and impairments involving virtually every organ system and overall quality of life. This likely reflects the joint contributions of pretransplantation treatment exposures and organ dysfunction, the transplantation conditioning regimen, and any post-transplantation graft-versus-host disease (GVHD). In response, the Children's Oncology Group (COG) has created long-term follow-up guidelines (www.survivorshipguidelines.org) for survivors of childhood, adolescent, and young adult cancer, including those who were treated with HCT. Guideline task forces, consisting of HCT specialists, other pediatric oncologists, radiation oncologists, organ-specific subspecialists, nurses, social workers, other health care professionals, and patient advocates systematically reviewed the literature with regards to late effects after childhood cancer and HCT since 2002, with the most recent review completed in 2013. For the most recent review cycle, over 800 articles from the medical literature relevant to childhood cancer and HCT survivorship were reviewed, including 586 original research articles. Provided herein is an organ system based overview that emphasizes the most relevant COG recommendations (with accompanying evidence grade) for the long-term follow-up care of childhood HCT survivors (regardless of current age) based on a rigorous review of the available evidence. These recommendations cover both autologous and allogeneic HCT survivors, those who underwent transplantation for nonmalignant diseases, and those with a history of chronic GVHD. (C) 2016 American Society for Blood and Marrow Transplantation.

引用

页码：782 / 795

页数：14

共 112 条

[1]

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[2]

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