Brain serotonin transporter binding in non-depressed patients with Parkinson's disease

被引:147
作者
Guttman, M.
Boileau, I.
Warsh, J.
Saint-Cyr, J. A.
Ginovart, N.
McCluskey, T.
Houle, S.
Wilson, A.
Mundo, E.
Rusjan, P.
Meyer, J.
Kish, S. J.
机构
[1] Univ Toronto, Human Neurochem Pathol Lab, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada
[2] Ctr Movement Disorders, Markham, ON, Canada
[3] Univ Toronto, Lab Cellular & Mol Pathophysiol, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada
[4] Univ Hlth Network, Toronto Western Res Inst, Toronto, ON, Canada
[5] Univ Toronto, Vivian M Rakoff PET Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada
[6] Univ Milan, Dept Clin Sci Luigi Sacco, Dept Psychiat, I-20122 Milan, Italy
关键词
depression; Parkinson's disease; serotonin; serotonin transporter;
D O I
10.1111/j.1468-1331.2007.01727.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Early post-mortem data suggest that damage to brain serotonin neurones might play a role in some features (e.g., depression) of Parkinson's disease (PD). However, it is not known whether such damage is a typical characteristic of living patients with PD or whether the changes are regionally widespread. To address this question we measured, by positron emission tomography imaging, levels of the brain serotonin transporter (SERT), a marker for serotonin neurones, as inferred from binding of [C-11]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB), a second generation SERT radioligand, in subcortical and cerebral cortical brain areas of clinically advanced non-depressed (confirmed by structured psychiatric interview) patients with PD. SERT binding levels in PD were lower than those in controls in all examined brain areas, with the changes statistically significant in orbitofrontal cortex (-22%), caudate (-30%), putamen (-26%), and midbrain (-29%). However, only a slight non-significant reduction (-7%) was observed in dorsolateral pre-frontal cortex, an area implicated in major depression. Our imaging data suggests that a modest, regionally widespread loss of brain serotonergic innervation might be a common feature of advanced PD. Further investigation will be required to establish whether SERT binding is more or less decreased in those patients with PD who also have major depressive disorder.
引用
收藏
页码:523 / 528
页数:6
相关论文
共 24 条
[1]   VERTEILUNG DES 5-HYDROXYTRYPTAMINS (SEROTONIN) IM GEHIRN DES MENSCHEN UND SEIN VERHALTEN BEI PATIENTEN MIT PARKINSON-SYNDROM [J].
BERNHEIMER, H ;
BIRKMAYER, W ;
HORNYKIEWICZ, O .
KLINISCHE WOCHENSCHRIFT, 1961, 39 (20) :1056-+
[2]  
Burger C, 1997, J NUCL MED, V38, P1818
[3]   SEROTONINERGIC TERMINAL TRANSPORTERS ARE DIFFERENTIALLY AFFECTED IN PARKINSONS-DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY - AN AUTORADIOGRAPHIC STUDY WITH [H-3] CITALOPRAM [J].
CHINAGLIA, G ;
LANDWEHRMEYER, B ;
PROBST, A ;
PALACIOS, JM .
NEUROSCIENCE, 1993, 54 (03) :691-699
[4]   Positron emission tomography quantification of [11C]-DASB binding to the human serotonin transporter:: Modeling strategies [J].
Ginovart, N ;
Wilson, AA ;
Meyer, JH ;
Hussey, D ;
Houle, S .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (11) :1342-1353
[5]   [C-11]RTI-32 PET studies of the dopamine transporter in early dopa-naive Parkinson's disease: Implications for the symptomatic threshold [J].
Guttman, M ;
Burkholder, J ;
Kish, SJ ;
Hussey, D ;
Wilson, A ;
DaSilva, J ;
Houle, S .
NEUROLOGY, 1997, 48 (06) :1578-1583
[6]   Review of the therapeutic management of Parkinson's disease. Report of a joint task force of the European Federation of Neurological Societies (EFNS) and the Movement Disorder Society-European Section (MDS-ES). Part II: late (complicated) Parkinson's disease [J].
Horstink, M. ;
Tolosa, E. ;
Bonuccelli, U. ;
Deuschl, G. ;
Friedman, A. ;
Kanovsky, P. ;
Larsen, J. P. ;
Lees, A. ;
Oertel, W. ;
Poewe, W. ;
Rascol, O. ;
Sampaio, C. .
EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (11) :1186-1202
[7]   Imaging the serotonin transporter with positron emission tomography:: initial human studies with [11C]DAPP and [11C]DASB [J].
Houle, S ;
Ginovart, N ;
Hussey, D ;
Meyer, JH ;
Wilson, AA .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (11) :1719-1722
[8]   Serotonin transporter binding in patients with mood disorders:: a PET study with [11C](+)McN5652 [J].
Ichimiya, T ;
Suhara, T ;
Sudo, Y ;
Okubo, Y ;
Nakayama, K ;
Nankai, M ;
Inoue, M ;
Yasuno, F ;
Takano, A ;
Maeda, J ;
Shibuya, H .
BIOLOGICAL PSYCHIATRY, 2002, 51 (09) :715-722
[9]   Positron emission tomography of striatal serotonin transporters in Parkinson disease [J].
Kerenyi, L ;
Ricaurte, GA ;
Schretlen, DJ ;
McCann, U ;
Varga, J ;
Mathews, WB ;
Ravert, HT ;
Dannals, RF ;
Hilton, J ;
Wong, DF ;
Szabo, Z .
ARCHIVES OF NEUROLOGY, 2003, 60 (09) :1223-1229
[10]   Regional distribution of serotonin transporter protein in postmortem human brain - Is the cerebellum a SERT-free brain region? [J].
Kish, SJ ;
Furukawa, Y ;
Chang, LJ ;
Tong, JC ;
Ginovart, N ;
Wilson, A ;
Houle, S ;
Meyer, JH .
NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (02) :123-128