Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus

被引：84

作者：

Lobigs, M ^{[1
]}

Müllbacher, A ^{[1
]}

Wang, Y ^{[1
]}

Pavy, M ^{[1
]}

Lee, E ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Div Cell Biol & Immunol, Canberra, ACT 2601, Australia

来源：

JOURNAL OF GENERAL VIROLOGY | 2003年 / 84卷

关键词：

D O I：

10.1099/vir.0.18654-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have investigated the contribution of the interferon (IFN)-alpha/beta system, IFN-gamma and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-alpha/beta responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus.

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页码：567 / 572

页数：6

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