Thyroid hormone action during brain development: More questions than answers

被引：139

作者：

Horn, Sigrun ^{[1
]}

Heuer, Heike ^{[1
]}

机构：

[1] Fritz Lipmann Inst, Leibniz Inst Age Res, D-07745 Jena, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 315卷 / 1-2期

关键词：

Central nervous system; Neuronal differentiation; Thyroid hormone receptor; Deiodinase; Thyroid hormone transporter; MCT8; DEVELOPING RAT-BRAIN; TYPE-2 IODOTHYRONINE DEIODINASE; MESSENGER-RIBONUCLEIC-ACID; ORGANIC ANION TRANSPORTER; CELL-ADHESION MOLECULE; PSYCHOMOTOR RETARDATION; GENE-EXPRESSION; NERVOUS-SYSTEM; BLOOD-BRAIN; CONGENITAL HYPOTHYROIDISM;

D O I：

10.1016/j.mce.2009.09.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Thyroid hormone is essential for proper brain development since it acts on processes such as neuronal migration and differentiation, myelination and synaptogenesis. In this review, we summarize the consequences of thyroid hormone deficiency for brain development with special focus on the cerebellum, an important target of thyroid action. In addition, we discuss the role of iodothyronine deiodinases and thyroid hormone transporters in regulating local thyroid hormone concentrations as well as current knowledge about the function of thyroid hormone receptors and their target genes during brain maturation. Despite considerable progress in recent years in deciphering thyroid hormone signaling pathways we still know very little on the molecular level by which mode of action thyroid hormone exerts its cell-specific effects. Hence, we will particularly address the open questions that remain to be addressed in order to better understand the role of thyroid hormone in brain development. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：19 / 26

页数：8

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