CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats

被引：61

作者：

Borlongan, CV

Skinner, SJM

Geaney, M

Vasconcellos, AV

Elliott, RB

Emerich, DF

机构：

[1] Med Coll Georgia, Sch Grad Studies, Inst Mol & Med Genet, Dept Neurol, Augusta, GA 30912 USA

[2] Augusta VAMC, Res & Affiliat Serv Line, Augusta, GA USA

[3] LCTBioPharma Inc, Providence, RI USA

[4] DiatraNZ Living Cell Technol, Auckland, New Zealand

来源：

NEUROREPORT | 2004年 / 15卷 / 10期

关键词：

cell transplantation; cerebral ischemia; encapsulation; neurogenesis; neuroprotection; neurotrophic factors;

D O I：

10.1097/01.wnr.0000133298.84901.cf

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependant protection of embryonic cortical neurons against serum deprivation-induced cell death. In vivo studies demonstrated that a one-hour middle cerebral artery occlusion in adult Wistar rats produced profound motor and neurological impairments 1-3 days after stroke. In contrast, stroke animals transplanted with encapsulated choroid plexus cells displayed a significant reduction in both motor and neurological abnormalities. Histological analysis 3 days post-transplantation revealed that choroid plexus transplants significantly decreased the volume of striatal infarction. This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke.

引用

页码：1543 / 1547

页数：5

共 25 条

[1] CHOROID-PLEXUS AS A BARRIER TO IMMUNOGLOBULIN DELIVERY INTO CEREBROSPINAL-FLUID [J].