Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine

被引：10

作者：

Menezes, CMS

Kirchgatter, K

Di Santi, SMF

Savalli, C

Monteiro, FG

Paula, GA

Ferreira, EI

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05389970 Sao Paulo, Brazil

[2] Univ Estadual Paulista, Inst Ciencias Saude, Sao Paulo, Brazil

[3] Superintendencia Controle Endemias, Div Programas Especiais, Sao Paulo, Brazil

[4] Univ Sao Paulo, Inst Matemat & Estatist, Sao Paulo, Brazil

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1997年 / 91卷 / 06期

关键词：

malaria; Plasmodium falciparum; chemotherapy; drug resistance; chloroquine; desipramine; imipramine;

D O I：

10.1016/S0035-9203(97)90529-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu g/L for imipramine), but no reversal of resistance when added to cultures together with chloroquine.

引用

页码：697 / 700

页数：4

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