Localization of TGF-β and its receptors in the kidney

被引：18

作者：

Ando, T

Okuda, S

Yanagida, T

Fujishima, M

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 2, Higashi Ku, Fukuoka 81282, Japan

[2] Kurume Univ, Sch Med, Dept Internal Med 3, Fukuoka, Japan

来源：

MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 2-3期

关键词：

TGF-beta; LTBP; TGF-beta receptor;

D O I：

10.1159/000057363

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This paper reviews the expression and localization of proteins of the TGF-beta system in the kidney, i.e. TGF-beta isoforms, latent TGF-beta binding protein, and receptors. There is heterogeneity of TGF-beta isoforms, binding proteins and receptors. TGF-beta s are more evenly distributed among different segments of the nephron than TGF-beta receptors, and are expressed by almost all cell types in the kidney. The spatial distribution of TGF-beta and its signaling receptor may help to better understand the biologic function of TGF-beta in the kidney.

引用

页码：149 / 153

页数：5

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