Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration

被引：147

作者：

Li, J

Milne, RW ^{[1
]}

Nation, RL

Turnidge, JD

Smeaton, TC

Coulthard, K

机构：

[1] Univ S Australia, Sch Pharmaceut Mol & Biomed Sci, Pharmaceut Res Ctr, Adelaide, SA 5000, Australia

[2] Womens & Childrens Hosp, Dept Pharm, Adelaide, SA, Australia

[3] Womens & Childrens Hosp, Dept Microbiol & Infect Dis, Adelaide, SA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 05期

关键词：

D O I：

10.1128/AAC.47.5.1766-1770.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.

引用

页码：1766 / 1770

页数：5

共 29 条

[1] ABE M, 1976, CHEMOTHERAPY, V24, P1592
[2] PHARMACOLOGIC AND TOXICOLOGIC STUDIES WITH POLYMYXINS .2. COMPARATIVE PHARMACOLOGIC STUDIES OF SULFATE AND METHANESULFONATE SALTS OF POLYMYXIN-B AND COLISTIN IN DOGS
ALKHAYYAT, AA
ARONSON, AL
[J]. CHEMOTHERAPY, 1973, 19 (02) : 82 - 97
[3] The treatment of respiratory pseudomonas infection in cystic fibrosis - What drug and which way?
Banerjee, D
Stableforth, D
[J]. DRUGS, 2000, 60 (05) : 1053 - 1064
[4] Beringer P, 2001, Curr Opin Pulm Med, V7, P434, DOI 10.1097/00063198-200111000-00013
[5] OBSERVATIONS ON TEMPERATURE DISTRIBUTION AND LIVER BLOOD FLOW IN THE RAT
BIRNIE, JH
GRAYSON, J
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1952, 116 (02): : 189 - 201
[6] PHYSIOLOGICAL-PARAMETERS IN LABORATORY-ANIMALS AND HUMANS
DAVIES, B
MORRIS, T
[J]. PHARMACEUTICAL RESEARCH, 1993, 10 (07) : 1093 - 1095
[7] Hyphenated liquid chromatographic method for the determination of colistin residues in bovine tissues
Decolin, D
Leroy, P
Nicolas, A
Archimbault, P
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1997, 35 (12) : 557 - 564
[8] Polymyxin B sulfate and colistin: Old antibiotics for emerging multiresistant gram-negative bacteria
Evans, ME
Feola, DJ
Rapp, RP
[J]. ANNALS OF PHARMACOTHERAPY, 1999, 33 (09) : 960 - 967
[9] Surveillance of antibiotic resistance in European ICUs
Hanberger, H
Diekema, D
Fluit, A
Jones, R
Struelens, M
Spencer, R
Wolff, M
[J]. JOURNAL OF HOSPITAL INFECTION, 2001, 48 (03) : 161 - 176
[10] Peptide antibiotics
Hancock, REW
Chapple, DS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) : 1317 - 1323

← 1 2 3 →