5-HT1A receptor-regulated signal transduction pathways in brain

被引：205

作者：

Polter, Abigail M.

Li, Xiaohua ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA

来源：

CELLULAR SIGNALLING | 2010年 / 22卷 / 10期

关键词：

Serotonin; 5-HT1A receptors; G protein; MAPK; Akt; Behavior; ACTIVATED PROTEIN-KINASE; LONG-TERM POTENTIATION; FORCED SWIM TEST; GLYCOGEN-SYNTHASE KINASE-3-BETA; LEARNED HELPLESSNESS PARADIGM; HIPPOCAMPAL PYRAMIDAL CELLS; ADENYLATE-CYCLASE ACTIVITY; CENTRAL-NERVOUS-SYSTEM; DORSAL RAPHE NEURONS; ELEVATED PLUS-MAZE;

D O I：

10.1016/j.cellsig.2010.03.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1406 / 1412

页数：7

共 179 条

[1]

Agonist stimulation of the serotonin1A receptor causes suppression of anoxia-induced apoptosis via mitogen-activated protein kinase in neuronal HN2-5 cells [J].