Effects of ENU dosage on mouse strains

被引：115

作者：

Justice, MJ ^{[1
]}

Carpenter, DA

Favor, J

Neuhauser-Klaus, A

de Angelis, MH

Soewarto, D

Moser, A

Cordes, S

Miller, D

Chapman, V

Weber, JS

Rinchik, EM

Hunsicker, PR

Russell, WL

Bode, VC

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Oak Ridge Natl Lab, Div Life Sci, Oak Ridge, TN 37831 USA

[3] GSF, Natl Res Ctr Environm & Hlth, Neuherberg, Germany

[4] Univ Wisconsin, Dept Human Oncol, Madison, WI 53792 USA

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[7] Kansas State Univ, Div Biol, Manhattan, KS 66706 USA

来源：

MAMMALIAN GENOME | 2000年 / 11卷 / 07期

关键词：

D O I：

10.1007/s003350010094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F-1 hybrids to ENU. The results show that most F-1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.

引用

页码：484 / 488

页数：5

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