Gender differences in clinical presentation and surgical outcome of aortic stenosis

Background Little is known about the gender differences of patients undergoing aortic valve replacement (AVR) for isolated severe aortic stenosis. Methods and Results 408 consecutive patients (215 women and 193 men; p=0.9) were analysed. At presentation, women were older (73.7 +/- 9.3 years vs men 66.5 +/- 11.5 years; p<0.001), more symptomatic (New York Heart Association (NYHA) class: women 2.3 +/- 0.7 vs men 2.0 +/- 0.65; p<0.001), and presented with smaller valve areas (women 0.660.2 cm(2) vs men 0.7 +/- 0.2 cm(2); p<0.001) and higher mean pressure gradients (women 67.3 +/- 19.2 mm Hg vs men 62.2 +/- 20.0 mm Hg, p=0.001). Despite older age and more advanced disease in women, operative mortality did not differ. Survival after AVR by Kaplan-Meier analysis tended to be even better in women (92.8%, 89.8%, 81.4% vs men 89.1%, 86.6%, 76.3% at 1, 2 and 5 years, p=0.31). After division into age quintiles, the outcome of women was significantly better in patients older than 79 years (p=0.005). After adjustment for clinical characteristics, gender did not predict operative mortality and late outcome. Despite physical improvement in both groups after surgery, women remained more symptomatic (NYHA class: women 1.6 +/- 0.7 vs men 1.3 +/- 0.4; p=0.001). Conclusion Although women referred to AVR are older and more symptomatic, operative and long-term mortality are not increased. In the oldest age group of 79 years and older, women even have a better outcome, presumably due to a longer mean life expectancy.