T cells, dendritic cells and epithelial cells in intestinal homeostasis

被引：36

作者：

Westendorf, Astrid M. ^{[1
]}

Fleissner, Diana ^{[1
]}

Hansen, Wiebke ^{[1
]}

Buer, Jan ^{[1
]}

机构：

[1] Univ Hosp Essen, Inst Med Microbiol, D-45122 Essen, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2010年 / 300卷 / 01期

关键词：

Intestinal homeostasis; T cells; Dendritic cells; Intestinal epithelial cells; INFLAMMATORY-BOWEL-DISEASE; PROINFLAMMATORY GENE-EXPRESSION; TGF-BETA; ANTIGEN PRESENTATION; BACTERIAL LIGANDS; PROSTAGLANDIN E-2; ENDOGENOUS IL-10; LAMINA PROPRIA; ORAL TOLERANCE; CUTTING EDGE;

D O I：

10.1016/j.ijmm.2009.08.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mucosal immune system of the intestinal tract is continuously exposed to both potential pathogens and beneficial commensal microorganism. A variety of mechanisms contribute to the ability of the gut to either react or remain tolerant to antigen present in the intestinal lumen. Antigens of the gut commensals are not simply ignored, but rather trigger an active immunosuppressive process, which prevents the outcome of immunopathology. The aim of this review is to provide an update on the mechanism of intestinal homeostasis, with particular focus on the complex crosstalk between T cells, dendritic cells and intestinal epithelial cells. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：11 / 18

页数：8

共 101 条

[1] Decreased expression of toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide [J].

Abreu, MT ;

Vora, P ;

Faure, E ;

Thomas, LS ;

Arnold, ET ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1609-1616

[2] Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells [J].

Allez, M ;

Brimnes, J ;

Dotan, I ;

Mayer, L .

GASTROENTEROLOGY, 2002, 123 (05) :1516-1526

[3] Essential role for CD103 in the T cell-mediated regulation of experimental colitis [J].

Annacker, O ;

Coombes, JL ;

Malmstrom, V ;

Uhlig, HH ;

Bourne, T ;

Johansson-Lindbom, B ;

Agace, WW ;

Parker, CM ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1051-1061

[4] Defective regulatory and effector T cell functions in patients with FOXP3 mutations [J].

Bacchetta, Rosa ;

Passerini, Laura ;

Gambineri, Eleonora ;

Dai, Minyue ;

Allan, Sarah E. ;

Perroni, Lucia ;

Dagna-Bricarelli, Franca ;

Sartirana, Claudia ;

Matthes-Martins, Susanne ;

Lawitschka, Anita ;

Azzari, Chiara ;

Ziegler, Steven F. ;

Levings, Megan K. ;

Roncarolo, Maria Grazia .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (06) :1713-1722

[5] Migration and maturation of human colonic dendritic cells [J].

Bell, SJ ;

Rigby, R ;

English, N ;

Mann, SD ;

Knight, SC ;

Kamm, MA ;

Stagg, AJ .

JOURNAL OF IMMUNOLOGY, 2001, 166 (08) :4958-4967

[6] Cutting edge:: Autocrine TGF-β sustains default tolerogenesis by IDO-competent dendritic cells [J].

Belladonna, Maria L. ;

Volpi, Claudia ;

Bianchi, Roberta ;

Vacca, Camine ;

Orabona, Ciriana ;

Pallotta, Maria T. ;

Boon, Louis ;

Gizzi, Stefania ;

Fioretti, Maria C. ;

Grohmann, Ursula ;

Puccetti, Paolo .

JOURNAL OF IMMUNOLOGY, 2008, 181 (08) :5194-5198

[7] All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation [J].

Benson, Micah J. ;

Pino-Lagos, Karina ;

Rosemblatt, Mario ;

Noelle, Randolph J. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1765-1774

[8] Induction and effector functions of TH17 cells [J].

Bettelli, Estelle ;

Korn, Thomas ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2008, 453 (7198) :1051-1057

[9] Mucosal CD8α+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties [J].

Bilsborough, J ;

George, TC ;

Norment, A ;

Viney, JL .

IMMUNOLOGY, 2003, 108 (04) :481-492

[10] Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice [J].

Björck, P .

BLOOD, 2001, 98 (13) :3520-3526

← 1 2 3 4 5 6 7 8 9 10 →