JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia

被引:63
作者
Kraemer, Alwin
Reiter, Andreas
Kruth, Jens
Erben, Philipp
Hochhaus, Andreas
Mueller, Martin
Cross, Nicholas C. P.
Jones, Amy V.
Ho, Anthony D.
Hensel, Manfred
机构
[1] Univ Heidelberg, Dept Internal Med 5, D-69120 Heidelberg, Germany
[2] Univ Heidelberg, Fac Clin Med Mannheim, Dept Internal Med 3, Mannheim, Germany
[3] Wessex Reg Genet Lab, Salisbury, Wilts, England
关键词
D O I
10.1016/S1470-2045(07)70206-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:658 / 660
页数:3
相关论文
共 16 条
[1]   Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders [J].
Baxter, EJ ;
Scott, LM ;
Campbell, PJ ;
East, C ;
Fourouclas, N ;
Swanton, S ;
Vassiliou, GS ;
Bench, AJ ;
Boyd, EM ;
Curtin, N ;
Scott, MA ;
Erber, WN ;
Green, AR .
LANCET, 2005, 365 (9464) :1054-1061
[2]   Treatment of chronic myelogenous leukemia with the tyrosine kinase inhibitor STI571 results in marked regression of bone marrow fibrosis [J].
Beham-Schmid, C ;
Apfelbeck, U ;
Sill, H ;
Tsybrovsky, O ;
Höfler, G ;
Haas, OA ;
Linkesch, W .
BLOOD, 2002, 99 (01) :381-383
[3]   The Philadelphia translocation and pre-existing myeloproliferative disorders [J].
Curtin, NJ ;
Campbell, PJ ;
Green, AR .
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (05) :734-736
[4]   Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR [J].
Emig, M ;
Saussele, S ;
Wittor, H ;
Weisser, A ;
Reiter, A ;
Willer, A ;
Berger, U ;
Hehlmann, R ;
Cross, NCP ;
Hochhaus, A .
LEUKEMIA, 1999, 13 (11) :1825-1832
[5]   A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q 11.2) translocation in a patient with a clinically typical chronic myeloid leukemia [J].
Griesinger, F ;
Hennig, H ;
Hillmer, F ;
Podleschny, M ;
Steffens, R ;
Pies, A ;
Wörmann, B ;
Haase, D ;
Bohlander, SK .
GENES CHROMOSOMES & CANCER, 2005, 44 (03) :329-333
[6]   A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera [J].
James, C ;
Ugo, V ;
Le Couédic, JP ;
Staerk, J ;
Delhommeau, F ;
Lacout, C ;
Garçon, L ;
Raslova, H ;
Berger, R ;
Bennaceur-Griscelli, A ;
Villeval, JL ;
Constantinescu, SN ;
Casadevall, N ;
Vainchenker, W .
NATURE, 2005, 434 (7037) :1144-1148
[7]   JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia [J].
Jelinek, J ;
Oki, Y ;
Gharibyan, V ;
Bueso-Ramos, C ;
Prchal, JT ;
Verstovsek, S ;
Beran, M ;
Estey, E ;
Kantarjian, HM ;
Issa, JPJ .
BLOOD, 2005, 106 (10) :3370-3373
[8]   Minimal molecular response in polycythemia vera patients treated with imatinib or interferon alpha [J].
Jones, AV ;
Silver, RT ;
Waghorn, K ;
Curtis, C ;
Kreil, S ;
Zoi, K ;
Hochhaus, A ;
Oscier, D ;
Metzgeroth, G ;
Lengfelder, E ;
Reiter, A ;
Chase, AJ ;
Cross, NCP .
BLOOD, 2006, 107 (08) :3339-3341
[9]   Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders [J].
Jones, AV ;
Kreil, S ;
Zoi, K ;
Waghorn, K ;
Curtis, C ;
Zhang, LY ;
Score, J ;
Seear, R ;
Chase, AJ ;
Grand, FH ;
White, H ;
Zoi, C ;
Loukopoulos, D ;
Terpos, E ;
Vervessou, EC ;
Schultheis, B ;
Emig, M ;
Ernst, T ;
Lengfelder, E ;
Hehlmann, R ;
Hochhaus, A ;
Oscier, D ;
Silver, RT ;
Reiter, A ;
Cross, NCP .
BLOOD, 2005, 106 (06) :2162-2168
[10]   A gain-of-function mutation of JAK2 in myeloproliferative disorders [J].
Kralovics, R ;
Passamonti, F ;
Buser, AS ;
Teo, S ;
Tiedt, R ;
Passweg, JR ;
Tichelli, A ;
Cazzola, M ;
Skoda, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (17) :1779-1790