Angiogenesis in ischemic and neoplastic disorders

被引：333

作者：

Semenza, GL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2003年 / 54卷

关键词：

angiopoietin; coronary collateral; hypoxia-inducible factor 1; infarction; vascular endothelial growth factor;

D O I：

10.1146/annurev.med.54.101601.152418

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Vascular development involves vasculogenesis, in which endothelial cells form a primary tubular network, as well as angiogenesis, in which vessel size and structure are modified based upon flow and branching occurs to insure that all cells receive adequate O-2 delivery. In adults, angiogenesis occurs in response to tissue hypoxia/ischemia and plays an important role in determining the progression of ischemic heart disease and cancer. A critical molecular pathway induced by hypoxia/ischemia is the activation of hypoxia-inducible factor 1, a transcriptional activator of genes encoding vascular endothelial growth factor and other important mediators of angiogenesis. Novel therapeutic approaches that involve stimulating angiogenesis in ischemic tissue and inhibiting angiogenesis in neoplastic tissue are currently being evaluated in clinical trials.

引用

页码：17 / 28

页数：12

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