Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria

被引:29
作者
Cavallo-Perin, P
Lupia, E
Gruden, G
Olivetti, C
De Martino, A
Cassader, M
Furlani, D
Servillo, L
Quagliuolo, L
Iorio, E
Boccellino, MR
Montrucchio, G
Camussi, G
机构
[1] Univ Turin, Dept Internal Med, Cattedra Nefrol, Lab Immunopatol, I-10126 Turin, Italy
[2] Univ Turin, Dept Clin Pathophysiol, I-10126 Turin, Italy
[3] Univ Naples 2, Dept Biochem & Biophys, Naples, Italy
关键词
PAF; diabetes; microalbuminuria; exercise;
D O I
10.1093/ndt/15.7.994
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Background. Platelet-activating factor (PAF), a phospholipid mediator of inflammation, may induce an enhanced size- and charge-dependent glomerular permeability in experimental animals. Studies on the role of PAF in enhanced glomerular permeability in the early phase of diabetic nephropathy are still lacking. Methods. We evaluated the intravascular levels of PAF and its main catabolic enzyme, the PAF-specific plasma acetyl-hydrolase (PAF-AH), in basal conditions and after exercise, in normo- or micro-albuminuric insulin-dependent diabetic (IDD) patients and in normal subjects. Results, The results obtained indicate that the concentration of PAF in whole blood was significantly enhanced in basal conditions, during and after exercise in all microalbuminuric IDD patients, but not in normoalbuminuric IDD or in control subjects. The increased concentration of PAF did not correlate with changes in the activity of PAF-AH, suggesting an enhanced production rather than a decreased catabolism of PAF. Conclusions. These results indicate an association between increased production of PAF and enhanced glomerular permeability in microalbuminuric IDD patients.
引用
收藏
页码:994 / 999
页数:6
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