Evaluation of a high-density oligonucleotide array for characterization of grlA, grlB, gyrA and gyrB mutations in fluoroquinolone resistant Staphylococcus aureus isolates

被引：10

作者：

Couzinet, S

Yugueros, J

Barras, C

Visomblin, N

Francois, P

Lacroix, B

Vernet, G

Lew, D

Troesch, A

Schrenzel, J

Jay, C ^{[1
]}

机构：

[1] BioMerieux SA, F-69280 Marcy LEtoile, France

[2] Univ Hosp Geneva, Div Infect Dis, CH-1211 Geneva 14, Switzerland

来源：

JOURNAL OF MICROBIOLOGICAL METHODS | 2005年 / 60卷 / 02期

关键词：

Staphylococcus aureus; DNA array; fluoroquinolone; resistance;

D O I：

10.1016/j.mimet.2004.09.015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Using high-density oligonucleotide array technology, 30 Staphylococcus aureus strains were studied for the presence of mutations in genes involved in fluoroquinolone resistance: grlA, gyrA: grlB and gyrB. For the two most important genes. gyrA and grlA, correlation with sequencing reached 95.1%. If all genes were considered, correlation was 88.8%. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：275 / 279

页数：5

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