In vivo role of CLC chloride channels in the kidney

被引：57

作者：

Uchida, S ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Internal Med 2, Sch Med, Tokyo 1138519, Japan

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2000年 / 279卷 / 05期

关键词：

knockout mice; immunohistochemistry; nephrogenic diabetes insipidus; Bartter's syndrome; Dent's disease;

D O I：

10.1152/ajprenal.2000.279.5.F802

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Chloride channels in the kidney are involved in important physiological functions such as cell volume regulation, acidification of intracellular vesicles, and transepithelial chloride transport. Among eight mammalian CLC chloride channels expressed in the kidney, three (CLC-K1, CLC-K2, and CLC-5) were identified to be related to kidney diseases in humans or mice. CLC-K1 mediates a transepithelial chloride transport in the thin ascending limb of Henle's loop and is essential for urinary concentrating mechanisms. CLC-K2 is a basolateral chloride channel in distal nephron segments and is necessary for chloride reabsorption. CLC-5 is a chloride channel in intracellular vesicles of proximal tubules and is involved in endocytosis. This review will cover the recent advances in research on the CLC chloride channels of the kidney with a special focus on the issues most necessary to understand their physiological roles in vivo, i. e., their intrarenal and cellular localization and their phenotypes of humans and mice that have their loss-of-function mutations.

引用

页码：F802 / F808

页数：7

共 52 条

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