Short-course of oral miltefosine for treatment of visceral leishmaniasis

被引：103

作者：

Sundar, S

Makharia, A

More, DK

Agrawal, G

Voss, A

Fischer, C

Bachmann, P

Murray, HW

机构：

[1] Banaras Hindu Univ, Inst Med Sci, Kala Azar Med Res Ctr, Varanasi 221005, Uttar Pradesh, India

[2] ASTA Medica AG, Frankfurt, Germany

[3] Cornell Univ, Weill Med Coll, New York, NY USA

[4] Cornell Univ, Weill Med Coll, Dept Med, New York, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2000年 / 31卷 / 04期

关键词：

D O I：

10.1086/318122

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 54 Indian patients with visceral leishmaniasis were treated with oral miltefosine, 50 mg given twice daily, for 14 days (18 patients; group A), 21 days (18; group B), or 28 days (18; group C). Cure was achieved in 89% of group A, 100% of group B, and 100% of group C. Adverse reactions were self-limited and primarily mild. The 21-day miltefosine regimen combines high-level efficacy, convenient dosing, and a relatively short duration.

引用

页码：1110 / 1113

页数：4

共 11 条

[1]

DANHAUSERRIEDL S, 1991, ONKOLOGIE, V14, P392

[2] Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis [J].

Jha, TK ;

Sundar, S ;

Thakur, CP ;

Bachmann, P ;

Karbwang, J ;

Fischer, C ;

Voss, A ;

Berman, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (24) :1795-1800

[3] Randomised controlled trial of aminosidine (paromomycin) υ sodium stibogluconate for treating visceral leishmaniasis in North Bihar, India [J].

Jha, TK ;

Olliaro, P ;

Thakur, CPN ;

Kanyok, TP ;

Singhania, BL ;

Singh, IJ ;

Singh, NKP ;

Akhoury, S ;

Jha, S .

BRITISH MEDICAL JOURNAL, 1998, 316 (7139) :1200-1205

[4]

JUNG RK, 1998, EPIDEMIOLOGICAL SITU, P78

[5]

KARNOFSKY D, 1961, CLIN PHARMACOL THER, V2, P709

[6]

More, 2000, CLIN INFECT DIS, V31

[7]

Sundar S, 1999, ANN TROP MED PARASIT, V93, P589, DOI 10.1080/00034989958096

[8] Trial of oral miltefosine for visceral leishmaniasis [J].

Sundar, S ;

Rosenkaimer, F ;

Makharia, MK ;

Goyal, AK ;

Mandal, AK ;

Voss, A ;

Hilgard, P ;

Murray, HW .

LANCET, 1998, 352 (9143) :1821-1823

[9] Short-course, low-dose amphotericin B lipid complex therapy for visceral leishmaniasis unresponsive to antimony [J].

Sundar, S ;

Agrawal, NK ;

Sinha, PR ;

Horwith, GS ;

Murray, HW .

ANNALS OF INTERNAL MEDICINE, 1997, 127 (02) :133-137

[10]

Thakur CP, 1998, ANN TROP MED PARASIT, V92, P561, DOI 10.1080/00034989859258

← 1 2 →