Genetics of inflammation and atopy

被引：7

作者：

Hurme, M ^{[1
]}

Pessi, T

Karjalainen, J

机构：

[1] Tampere Univ, Sch Med, Dept Microbiol & Immunol, FI-33014 Tampere, Finland

[2] Tampere Univ Hosp, Tampere, Finland

来源：

ANNALS OF MEDICINE | 2003年 / 35卷 / 04期

关键词：

atopy; gene polymorphism; inflammation; interleukin;

D O I：

10.1080/07853890310000682

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple chromosomal regions and polymorphisms of several candidate genes have been linked to or associated with atopic diseases (hayfever, asthma, allergic eczema and rhinitis). In this mini-review, we present data demonstrating that the genetic regulation of the inflammatory response makes a major contribution to the risk of atopy. These data also suggest that the quantity (or quality) of the inflammation affects the priming phase of atopy, i.e., that induced by allergens or infectious agents in early childhood.

引用

页码：256 / 258

页数：3

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