Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats

被引：60

作者：

Tanida, M

Iwashita, S

Ootsuka, Y

Terui, N

Suzuki, M ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Hlth & Sport Sci, Lab Exercise & Nutr, Tsukuba, Ibaraki 3058574, Japan

[2] Univ Tsukuba, Inst Basic Med Sci, Lab Exercise & Nutr, Tsukuba, Ibaraki 3058574, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 293卷 / 02期

关键词：

leptin; renal sympathetic nerves activity; blood pressure; white adipose tissue; afferent nerve; rat;

D O I：

10.1016/S0304-3940(00)01490-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies suggested that leptin in white adipose tissue (WAT) affected the sympathetic out flow to several tissues. We examined whether elevations of renal sympathetic nerve activity (RSNA) and blood pressure (BP) could be observed by leptin injection into WAT in rats. Injections of leptin (10 and 100 ng/ml per kg) into WAT evoked the activation of RSNA dose-dependently. Circulating sympathetic nerve activators, such as leptin, insulin, glucose and lactate, were unchanged by any doses of leptin. In addition, BP was not affected by leptin injections during a 90 min experimental period. These data suggested that leptin activated the afferent nerves through the sensors in WAT, resulting in elevation of RSNA. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：107 / 110

页数：4

共 18 条

[1] Leptin enters the brain by a saturable system independent of insulin [J].