Construction of the "Left domain" of haplophytine

被引：56

作者：

Nicolaou, K. C.

Majumder, Utpal

Roche, Stephane Philippe

Chen, David Y. -K.

机构：

[1] Inst Chem & Engn Sci, Agcy Sci Technol & Res, Chem Synthesis Lab Biopolis, Singapore 138667, Singapore

[2] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 25期

关键词：

alkaloids; natural products; nitrogen heterocycles; rearrangement; total synthesis;

D O I：

10.1002/anie.200701947

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Left of the middle: Synthesis of the left" structural domain (2) of haplophytine (1) features a stereoselective construction of its sterically congested carbon-carbon bond (C9′-C15) and an efficient cascade sequence involving a skeletal rearrangement of a presumed epoxide intermediate. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：4715 / 4718

页数：4

共 19 条

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